vasometrix is to blood pressure monitoring as the iphone is to telephony: making phone calls is not its top treasured talent.

Dr. Lutz E. Kraushaar

"A man is as old as his arteries."

Thomas Sydenham, 1624 - 1689

The Problem

Atherosclerotic disease goes hand in glove with a progressive decline of vascular function.

But so does aging.

To differentiate between the two is beyond the capability of clinical practice.

The result: underestimation of future cardiovascular morbidity and mortality in young adults, overestimation of risk in older adults, and poor efficiency in preventing CV disease mortality (Wald, Simmonds, & Morris, 2011).

"…traditional risk factors fail to predict future CVD in up to 50% of cases."

Prof. Dick H.J. Thijssen, J. Physiol 594.8

The Challenge

To develop a non-invasive assessment of all the parameters that define vascular function (Pereira, 2016; D. H. Thijssen, Carter, & Green, 2015).

Because the two surrogates that we have (pulse wave velocity, PWV; and flow mediated vasodilatation, FMD) correlate poorly with what they are supposed to measure

(Lutz E. Kraushaar, Dressel, & Massmann, 2018).

Functionomics is to aging what genomics is to inheritance. With one fascinating difference: You can change your functionome.

The Solution

…vasometrix, with its 3 strategies​:

  1. "functionomic" profiling for all relevant physical parameters of global vascular function.

  2. translating the functionomic profile into vascular biological age.

  3. doing number 1 & 2 "on the cheap": that is, by using conventional blood pressure monitoring (BPM) devices to extract functionomic data and BioAge.

Which makes for an attractively cost effective, user-friendly  and scalable solution.

In a nutshell:

vasometrix equips conventional  BPM devices with cutting-edge diagnostics for cardiovascular risk, function and age.

The Benefits.

  • For pharmaceuticals and clinical research: substantial reductions in costs and durations of phase III and other clinical trials.

  • For BPM device manufacturers: a unique competitive selling point.

  • For public health: low-cost scalability and the resulting prospect of substantial reductions in CVD morbidity and mortality.

How it works

Imagine…

your digital "avatar".

You "feed" him a recording of your pulse pressure wave, he replicates it, and returns a precise analysis of your vascular function.

I helped conceive and test this avatar and I named it "arteroid", a 721-element Windkessel electronic replication of the human arterial tree.

 

Arteroid's (digital) DNA: the electric-hydraulic analogy.

 

It states that each and every parameter of the tree's hemodynamic function has an exact electronic equivalent.

Once you know either one, you automatically know the other.

  • resistance = resistance,

  • arterial compliance = capacitance,

  • pressure = voltage,

  • flow = current,

  • inertia = inductance.

Why it is so accurate

Using evolutionary algorithms, the arteroid manipulates these electronic equivalents to replicate a person's non-invasively acquired pulse pressure curve with high fidelity (typically >99%).

The resulting electronic parameters represent their hemodynamic equivalents. 

That's how to uncover the functional profile of a person's arterial vasculature.

 

For a detailed description refer to appendix 1 of (Lutz E. Kraushaar, Dressel, & Massmann, 2018).

 

It's the functional equivalent of genomics: a person's individual functionome.

arteroid's strength is its greatest weakness

Arteroid's handicap: the required computing time and the hardware cost.

They make it too slow and too expensive for routine clinical practice.

 

That's why I conceived of vasometrix.

Think of vasometrix as the arteroid's clone:

 

A proprietary algorithm that replicates the arteroid's capabilities.

 

But at a fraction of arteroid's cost and time, and,…

…better still,…

 

…vasometrix can be calibrated to the pulse pressure wave recordings of ANY conventional BPM device.

Contact me if you want that for your company's devices.

© Dr. Lutz E. Kraushaar, Werbach, Germany